Cell atlas - SPTLC3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SPTLC3

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules

Human cell
	Microtubules

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	SPTLC3
Gene description	Serine palmitoyltransferase, long chain base subunit 3
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules.
RNA cell category	Cell line enhanced (U-87 MG, RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA048079
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG, RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules.

Main location

Microtubules (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048079	Hep G2	Microtubules
	HPA048079	RT4	Microtubules
	HPA048079	U-2 OS	Microtubules

GENE INFORMATION
Gene name	SPTLC3 (HGNC Symbol)
Synonyms	C20orf38, FLJ11112, hLCB2b, LCB2B, SPTLC2L
Description	Serine palmitoyltransferase, long chain base subunit 3 (HGNC Symbol)
Entrez gene summary	The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT; EC 2.3.1.50), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al., 2006 [PubMed 17023427]). SPT contains 2 main subunits: the common SPTLC1 subunit (MIM 605712) and either SPTLC2 (MIM 605713) or its isoform SPTLC2L (SPTLC3), depending on the tissue in which biosynthesis occurs (Hornemann et al., 2006 [PubMed 17023427]). There are also 2 highly related isoforms of a third subunit, SSSPTA (MIM 613540) and SSSPTB (MIM 610412), that confer acyl-CoA preference of the SPT enzyme and are essential for maximal enzyme activity (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]
Chromosome	20
Cytoband	p12.1
Chromosome location (bp)	13008979 - 13169103
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172296 (version 83.38)
Entrez gene	55304
UniProt	Q9NUV7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NUV7
Antibodypedia	SPTLC3 antibodies

PROTEIN BROWSER

SPTLC3-001	SPTLC3-002	SPTLC3-003	SPTLC3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPTLC3-001 ENSP00000389749 ENST00000434210	B1AKS2 [Direct mapping] Serine palmitoyltransferase 3; Serine palmitoyltransferase, long chain base subunit 2-like (Aminotransferase 2) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008483 [transaminase activity] GO:0016021 [integral component of membrane] Show all	139 aa 16 kDa	No	1
SPTLC3-002 ENSP00000409125 ENST00000450297	B1AKS3 [Direct mapping] Serine palmitoyltransferase 3; Serine palmitoyltransferase, long chain base subunit 2-like (Aminotransferase 2) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008483 [transaminase activity] Show all	215 aa 24.8 kDa	No	1
SPTLC3-003 ENSP00000409760 ENST00000431275	H0Y733 [Direct mapping] Serine palmitoyltransferase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] Show all	121 aa 13.3 kDa	No	0
SPTLC3-006 ENSP00000381968 ENST00000399002	Q9NUV7 [Direct mapping] Serine palmitoyltransferase 3 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004758 [serine C-palmitoyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0008152 [metabolic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016740 [transferase activity] GO:0017059 [serine C-palmitoyltransferase complex] GO:0030148 [sphingolipid biosynthetic process] GO:0030170 [pyridoxal phosphate binding] GO:0044281 [small molecule metabolic process] GO:0046520 [sphingoid biosynthetic process] Show all	552 aa 62 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.