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SPTLC3

GENERAL INFORMATION

Gene name

 SPTLC3

Gene description

 Serine palmitoyltransferase, long chain base subunit 3

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (skin)
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA044247
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 SPTLC3 (HGNC Symbol)

Synonyms

 C20orf38, FLJ11112, hLCB2b, LCB2B, SPTLC2L

Description

 Serine palmitoyltransferase, long chain base subunit 3 (HGNC Symbol)

Entrez gene summary

 The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT; EC 2.3.1.50), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al., 2006 [PubMed 17023427]). SPT contains 2 main subunits: the common SPTLC1 subunit (MIM 605712) and either SPTLC2 (MIM 605713) or its isoform SPTLC2L (SPTLC3), depending on the tissue in which biosynthesis occurs (Hornemann et al., 2006 [PubMed 17023427]). There are also 2 highly related isoforms of a third subunit, SSSPTA (MIM 613540) and SSSPTB (MIM 610412), that confer acyl-CoA preference of the SPT enzyme and are essential for maximal enzyme activity (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]

Chromosome

 20

Cytoband

 p12.1

Chromosome location (bp)

 13008979 - 13169103

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172296 (version 83.38)

Entrez gene

 55304

UniProt

 Q9NUV7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NUV7

Antibodypedia

 SPTLC3 antibodies

PROTEIN BROWSER
SPTLC3-001
SPTLC3-002
SPTLC3-003
SPTLC3-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPTLC3-001
ENSP00000389749
ENST00000434210
B1AKS2 [Direct mapping]
Serine palmitoyltransferase 3; Serine palmitoyltransferase, long chain base subunit 2-like (Aminotransferase 2)
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0008483 [transaminase activity]
GO:0016021 [integral component of membrane]
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 139 aa
16 kDa 		No 1
SPTLC3-002
ENSP00000409125
ENST00000450297
B1AKS3 [Direct mapping]
Serine palmitoyltransferase 3; Serine palmitoyltransferase, long chain base subunit 2-like (Aminotransferase 2)
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0008483 [transaminase activity]
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 215 aa
24.8 kDa 		No 1
SPTLC3-003
ENSP00000409760
ENST00000431275
H0Y733 [Direct mapping]
Serine palmitoyltransferase 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
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 121 aa
13.3 kDa 		No 0
SPTLC3-006
ENSP00000381968
ENST00000399002
Q9NUV7 [Direct mapping]
Serine palmitoyltransferase 3
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004758 [serine C-palmitoyltransferase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006665 [sphingolipid metabolic process]
GO:0008152 [metabolic process]
GO:0009058 [biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016740 [transferase activity]
GO:0017059 [serine C-palmitoyltransferase complex]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0044281 [small molecule metabolic process]
GO:0046520 [sphingoid biosynthetic process]
Show all
 552 aa
62 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.