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MARCH3

GENERAL INFORMATION

Gene name

 MARCH3

Gene description

 Membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at transcript level

Protein expression

 RNA-based expert annotation gave inconclusive results.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA043406
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MARCH3 (HGNC Symbol)

Synonyms

 MARCH-III, MGC48332, RNF173

Description

 Membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]

Chromosome

 5

Cytoband

 q23.2

Chromosome location (bp)

 126867714 - 127030808

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000173926 (version 83.38)

Entrez gene

 115123

UniProt

 Q86UD3 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q86UD3

Antibodypedia

 MARCH3 antibodies

PROTEIN BROWSER
MARCH3-001
MARCH3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MARCH3-001
ENSP00000309141
ENST00000308660
Q86UD3 [Direct mapping]
E3 ubiquitin-protein ligase MARCH3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0006897 [endocytosis]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031901 [early endosome membrane]
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 253 aa
28.5 kDa 		No 2
MARCH3-002
ENSP00000421979
ENST00000515241
Q86UD3 [Direct mapping]
E3 ubiquitin-protein ligase MARCH3
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Predicted intracellular proteins
Show all
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0006897 [endocytosis]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031901 [early endosome membrane]
Show all
 138 aa
15.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.