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REP15

GENERAL INFORMATION

Gene name

 REP15

Gene description

 RAB15 effector protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (stomach, rectum)
GTEx:Group enriched (stomach, small intestine, colon, testis)
FANTOM5:Group enriched (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic staining most abundant in glandular cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA040448 , HPA059868
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach, rectum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (stomach, small intestine, colon, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)

GENE INFORMATION

Gene name

 REP15 (HGNC Symbol)

Synonyms

 RAB15EP

Description

 RAB15 effector protein (HGNC Symbol)

Entrez gene summary

 REP15 is a binding partner of the RAB GTPase family member RAB15 that facilitates transferrin receptor (TFRC; MIM 190010) recycling from the endocytic recycling compartment (Strick and Elferink, 2005 [PubMed 16195351]).[supplied by OMIM, Mar 2008]

Chromosome

 12

Cytoband

 p11.22

Chromosome location (bp)

 27696519 - 27697596

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174236 (version 83.38)

Entrez gene

 387849

UniProt

 Q6BDI9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6BDI9

Antibodypedia

 REP15 antibodies

PROTEIN BROWSER
REP15-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
REP15-001
ENSP00000310335
ENST00000310791
Q6BDI9 [Direct mapping]
Rab15 effector protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001881 [receptor recycling]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005515 [protein binding]
GO:0010008 [endosome membrane]
GO:0031901 [early endosome membrane]
GO:0033572 [transferrin transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 236 aa
26.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.