We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Few cases of glioma, melanoma, breast, cervix, thyroid and urothelial cancers showed moderate nuclear staining. Several cases of prostate cancers exhibited moderate cytoplasmic, membranous and nuclear positivity. Remaining cancer tissues were weakly stained or negative.
Most cancer tissues showed weak nuclear and occasional cytoplasmic staining or were negative. Staining with moderate intensity was observed in thyroid cancers and gliomas.
GENE INFORMATION
Gene name
ZBTB4 (HGNC Symbol)
Synonyms
KAISO-L1, KIAA1538, ZNF903
Description
Zinc finger and BTB domain containing 4 (HGNC Symbol)
Q9P1Z0 [Direct mapping] Zinc finger and BTB domain-containing protein 4
Show all
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0008327 [methyl-CpG binding] GO:0010428 [methyl-CpNpG binding] GO:0019901 [protein kinase binding] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]
Q9P1Z0 [Direct mapping] Zinc finger and BTB domain-containing protein 4
Show all
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0008327 [methyl-CpG binding] GO:0010428 [methyl-CpNpG binding] GO:0019901 [protein kinase binding] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]
