Cell atlas - ZBTB4 - The Human Protein Atlas

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ZBTB4

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZBTB4
Gene description	Zinc finger and BTB domain containing 4
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (supported)
Additional location	In addition localized to the Nucleoplasm (supported), Cytosol (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA064763
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the cytosol & nucleoplasm.

Main location

Nuclear bodies (supported)

Additional location

Nucleoplasm (supported), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064763	HaCaT	Nucleoplasm
			Nuclear bodies	Intensity
			Cytosol
	HPA064763	U-2 OS	Nucleoplasm
			Nuclear bodies
			Cytosol
	HPA064763	U-251 MG	Nucleoplasm
	HPA064763	U-251 MG	Nuclear bodies	Intensity

GENE INFORMATION
Gene name	ZBTB4 (HGNC Symbol)
Synonyms	KAISO-L1, KIAA1538, ZNF903
Description	Zinc finger and BTB domain containing 4 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7459366 - 7484263
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174282 (version 83.38)
Entrez gene	57659
UniProt	Q9P1Z0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P1Z0
Antibodypedia	ZBTB4 antibodies

PROTEIN BROWSER

ZBTB4-001	ZBTB4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZBTB4-001 ENSP00000307858 ENST00000311403	Q9P1Z0 [Direct mapping] Zinc finger and BTB domain-containing protein 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0008327 [methyl-CpG binding] GO:0010428 [methyl-CpNpG binding] GO:0019901 [protein kinase binding] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1013 aa 105.1 kDa	No	0
ZBTB4-002 ENSP00000369973 ENST00000380599	Q9P1Z0 [Direct mapping] Zinc finger and BTB domain-containing protein 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0008327 [methyl-CpG binding] GO:0010428 [methyl-CpNpG binding] GO:0019901 [protein kinase binding] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1013 aa 105.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.