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HRAS

GENERAL INFORMATION

Gene name

 HRAS

Gene description

 Harvey rat sarcoma viral oncogene homolog

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 2 antibodies.
HPA049830 , CAB002015
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HRAS (HGNC Symbol)

Synonyms

 HRAS1

Description

 Harvey rat sarcoma viral oncogene homolog (HGNC Symbol)

Entrez gene summary

 This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 532242 - 537287

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174775 (version 83.38)

Entrez gene

 3265

UniProt

 P01112 (UniProt - Evidence at protein level)

neXtProt

 NX_P01112

Antibodypedia

 HRAS antibodies

PROTEIN BROWSER
HRAS-002
HRAS-004
HRAS-009
HRAS-201
HRAS-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HRAS-002
ENSP00000309845
ENST00000311189
P01112 [Direct mapping]
GTPase HRas GTPase HRas, N-terminally processed
X5D945 [Target identity:100%; Query identity:100%]
Harvey rat sarcoma viral oncoprotein isoform A; V-Ha-ras Harvey rat sarcoma viral oncogene homolog, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0007050 [cell cycle arrest]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0010629 [negative regulation of gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030335 [positive regulation of cell migration]
GO:0034260 [negative regulation of GTPase activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050900 [leukocyte migration]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090303 [positive regulation of wound healing]
GO:0090398 [cellular senescence]
GO:1900029 [positive regulation of ruffle assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
GO:2000630 [positive regulation of miRNA metabolic process]
Show all
 189 aa
21.3 kDa 		No 0
HRAS-004
ENSP00000380722
ENST00000397594
P01112 [Direct mapping]
GTPase HRas GTPase HRas, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0007050 [cell cycle arrest]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0010629 [negative regulation of gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030335 [positive regulation of cell migration]
GO:0034260 [negative regulation of GTPase activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050900 [leukocyte migration]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090303 [positive regulation of wound healing]
GO:0090398 [cellular senescence]
GO:1900029 [positive regulation of ruffle assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
GO:2000630 [positive regulation of miRNA metabolic process]
Show all
 170 aa
18.9 kDa 		No 0
HRAS-009
ENSP00000380723
ENST00000397596
P01112 [Direct mapping]
GTPase HRas GTPase HRas, N-terminally processed
X5D945 [Target identity:100%; Query identity:100%]
Harvey rat sarcoma viral oncoprotein isoform A; V-Ha-ras Harvey rat sarcoma viral oncogene homolog, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0007050 [cell cycle arrest]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0010629 [negative regulation of gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030335 [positive regulation of cell migration]
GO:0034260 [negative regulation of GTPase activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050900 [leukocyte migration]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090303 [positive regulation of wound healing]
GO:0090398 [cellular senescence]
GO:1900029 [positive regulation of ruffle assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
GO:2000630 [positive regulation of miRNA metabolic process]
Show all
 189 aa
21.3 kDa 		No 0
HRAS-201
ENSP00000388246
ENST00000417302
P01112 [Direct mapping]
GTPase HRas GTPase HRas, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0007050 [cell cycle arrest]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0010629 [negative regulation of gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030335 [positive regulation of cell migration]
GO:0034260 [negative regulation of GTPase activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050900 [leukocyte migration]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090303 [positive regulation of wound healing]
GO:0090398 [cellular senescence]
GO:1900029 [positive regulation of ruffle assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
GO:2000630 [positive regulation of miRNA metabolic process]
Show all
 170 aa
18.9 kDa 		No 0
HRAS-202
ENSP00000407586
ENST00000451590
P01112 [Direct mapping]
GTPase HRas GTPase HRas, N-terminally processed
X5D945 [Target identity:100%; Query identity:100%]
Harvey rat sarcoma viral oncoprotein isoform A; V-Ha-ras Harvey rat sarcoma viral oncogene homolog, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0007050 [cell cycle arrest]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030335 [positive regulation of cell migration]
GO:0034260 [negative regulation of GTPase activity]
GO:0035176 [social behavior]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050900 [leukocyte migration]
GO:0051291 [protein heterooligomerization]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090303 [positive regulation of wound healing]
GO:0090398 [cellular senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900029 [positive regulation of ruffle assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
GO:2000630 [positive regulation of miRNA metabolic process]
Show all
 189 aa
21.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.