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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CADM2
  • premium

    TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Cell adhesion molecule 2

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA010024

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong staining of neuropil in gliomas. All other cancer tissues were negative.

GENE INFORMATION

Gene name

CADM2 (HGNC Symbol)

Synonyms

IGSF4D, Necl-3, NECL3, SynCAM2

Description

Cell adhesion molecule 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

3

Cytoband

p12.1

Chromosome location (bp)

84958981 - 86074429

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175161 (version 83.38)

Entrez gene

253559

UniProt

Q8N3J6 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8N3J6

Antibodypedia

CADM2 antibodies

PROTEIN BROWSER

CADM2-001
CADM2-002
CADM2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CADM2-001
ENSP00000384193
ENST00000405615
Q8N3J6 [Direct mapping]
Cell adhesion molecule 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0030424 [axon]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0050839 [cell adhesion molecule binding]
Show all
437 aa
47.6 kDa
Yes 1
CADM2-002
ENSP00000373200
ENST00000383699
Q8N3J6 [Direct mapping]
Cell adhesion molecule 2
G3XHN4 [Target identity:100%; Query identity:100%]
Cell adhesion molecule 2 isoform 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0030424 [axon]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0050839 [cell adhesion molecule binding]
Show all
404 aa
44.4 kDa
Yes 1
CADM2-006
ENSP00000384575
ENST00000407528
Q8N3J6 [Direct mapping]
Cell adhesion molecule 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0030424 [axon]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0050839 [cell adhesion molecule binding]
Show all
435 aa
47.6 kDa
Yes 1

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