Tissue expression of CADM2 - Summary - The Human Protein Atlas

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CADM2

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CADM2
Gene description	Cell adhesion molecule 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (cerebral cortex, cerebellum, caudate, hippocampus, hypothalamus)
FANTOM5:	Tissue enhanced (cerebellum, hippocampus, caudate)

Protein evidence

Evidence at protein level

Protein expression

Distinct expression in CNS and peripheral nerve fibers.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA010024
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, cerebellum, caudate, hippocampus, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, hippocampus, caudate)

GENE INFORMATION
Gene name	CADM2 (HGNC Symbol)
Synonyms	IGSF4D, Necl-3, NECL3, SynCAM2
Description	Cell adhesion molecule 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	3
Cytoband	p12.1
Chromosome location (bp)	84958981 - 86074429
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175161 (version 83.38)
Entrez gene	253559
UniProt	Q8N3J6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N3J6
Antibodypedia	CADM2 antibodies

PROTEIN BROWSER

CADM2-001	CADM2-002	CADM2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CADM2-001 ENSP00000384193 ENST00000405615	Q8N3J6 [Direct mapping] Cell adhesion molecule 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0030424 [axon] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042803 [protein homodimerization activity] GO:0045202 [synapse] GO:0045216 [cell-cell junction organization] GO:0050839 [cell adhesion molecule binding] Show all	437 aa 47.6 kDa	Yes	1
CADM2-002 ENSP00000373200 ENST00000383699	Q8N3J6 [Direct mapping] Cell adhesion molecule 2 G3XHN4 [Target identity:100%; Query identity:100%] Cell adhesion molecule 2 isoform 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0030424 [axon] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042803 [protein homodimerization activity] GO:0045202 [synapse] GO:0045216 [cell-cell junction organization] GO:0050839 [cell adhesion molecule binding] Show all	404 aa 44.4 kDa	Yes	1
CADM2-006 ENSP00000384575 ENST00000407528	Q8N3J6 [Direct mapping] Cell adhesion molecule 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0030424 [axon] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042803 [protein homodimerization activity] GO:0045202 [synapse] GO:0045216 [cell-cell junction organization] GO:0050839 [cell adhesion molecule binding] Show all	435 aa 47.6 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.