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A subset of tumor cells in few cases of gliomas displayed strong cytoplasmic and nuclear staining. Several cases of melanomas, testis and liver cancers along with occasional cases of breast, urothelial and pancreatic cancers showed weak to moderate cytoplasmic staining. Remaining cancer tissues were negative.
Several squamous and basal cell carcinomas along with high grade urothelial cancers, breast and ovarian cancers displayed moderate membranous and cytoplasmic positivity. Remaining cancer cells were weakly stained or negative.
GENE INFORMATION
Gene name
ODF3 (HGNC Symbol)
Synonyms
CT135, hSHIPPO, SHIPPO1
Description
Outer dense fiber of sperm tails 3 (HGNC Symbol)
Entrez gene summary
ODF3 is a component of sperm flagella outer dense fibers, which add stiffness, elastic recoil, and protection against shearing forces during sperm movement.[supplied by OMIM, Apr 2004]
