Expression of OPLAH in cancer - Summary

CANCER ATLAS

Gene description

5-oxoprolinase (ATP-hydrolysing)

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Ovarian cancer

STAINING SUMMARY

HPA026562	HPA028260

GENE INFORMATION
Gene name	OPLAH (HGNC Symbol)
Synonyms	5-Opase, OPLA
Description	5-oxoprolinase (ATP-hydrolysing) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144051266 - 144063832
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178814 (version 83.38)
Entrez gene	26873
UniProt	O14841 (UniProt - Evidence at protein level)
neXtProt	NX_O14841
Antibodypedia	OPLAH antibodies

PROTEIN BROWSER

OPLAH-001	OPLAH-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OPLAH-001 ENSP00000480476 ENST00000618853	O14841 [Direct mapping] 5-oxoprolinase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006750 [glutathione biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0016787 [hydrolase activity] GO:0017168 [5-oxoprolinase (ATP-hydrolyzing) activity] GO:0044281 [small molecule metabolic process] GO:1901687 [glutathione derivative biosynthetic process] Show all	1288 aa 137.5 kDa	No	0
OPLAH-006 ENSP00000481640 ENST00000567871	A0A087WY99 [Direct mapping] 5-oxoprolinase Show all	Predicted intracellular proteins Show all		158 aa 17.2 kDa	No	0