Cell atlas - OPLAH - The Human Protein Atlas

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OPLAH

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	OPLAH
Gene description	5-oxoprolinase (ATP-hydrolysing)
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli (fibrillar center).
RNA cell category	Cell line enhanced (AN3-CA, PC-3, BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA052429
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA, PC-3, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli (fibrillar center).

Main location

Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA052429	PC-3	Nucleoli fibrillar center
	HPA052429	U-2 OS	Nucleoli fibrillar center

GENE INFORMATION
Gene name	OPLAH (HGNC Symbol)
Synonyms	5-Opase, OPLA
Description	5-oxoprolinase (ATP-hydrolysing) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144051266 - 144063832
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178814 (version 83.38)
Entrez gene	26873
UniProt	O14841 (UniProt - Evidence at protein level)
neXtProt	NX_O14841
Antibodypedia	OPLAH antibodies

PROTEIN BROWSER

OPLAH-001	OPLAH-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OPLAH-001 ENSP00000480476 ENST00000618853	O14841 [Direct mapping] 5-oxoprolinase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006750 [glutathione biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0016787 [hydrolase activity] GO:0017168 [5-oxoprolinase (ATP-hydrolyzing) activity] GO:0044281 [small molecule metabolic process] GO:1901687 [glutathione derivative biosynthetic process] Show all	1288 aa 137.5 kDa	No	0
OPLAH-006 ENSP00000481640 ENST00000567871	A0A087WY99 [Direct mapping] 5-oxoprolinase Show all	Predicted intracellular proteins Show all		158 aa 17.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.