Expression of GAK in cancer - Summary - The Human Protein Atlas

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GAK

TISSUE

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CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

Cyclin G associated kinase

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA027405	HPA027459	HPA027463

GENE INFORMATION
Gene name	GAK (HGNC Symbol)
Synonyms	DNAJC26
Description	Cyclin G associated kinase (HGNC Symbol)
Entrez gene summary	In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	849276 - 932373
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178950 (version 83.38)
Entrez gene	2580
UniProt	O14976 (UniProt - Evidence at protein level)
neXtProt	NX_O14976
Antibodypedia	GAK antibodies

PROTEIN BROWSER

GAK-001	GAK-002	GAK-010	GAK-011	GAK-015	GAK-020	GAK-201	GAK-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GAK-001 ENSP00000314499 ENST00000314167	O14976 [Direct mapping] Cyclin-G-associated kinase Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007030 [Golgi organization] GO:0007049 [cell cycle] GO:0010977 [negative regulation of neuron projection development] GO:0016020 [membrane] GO:0031982 [vesicle] GO:0043231 [intracellular membrane-bounded organelle] GO:0048471 [perinuclear region of cytoplasm] Show all	1311 aa 143.2 kDa	No	0
GAK-002 ENSP00000421361 ENST00000511163	O14976 [Direct mapping] Cyclin-G-associated kinase Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007030 [Golgi organization] GO:0007049 [cell cycle] GO:0010977 [negative regulation of neuron projection development] GO:0016020 [membrane] GO:0031982 [vesicle] GO:0043231 [intracellular membrane-bounded organelle] GO:0048471 [perinuclear region of cytoplasm] Show all	1232 aa 134.5 kDa	No	0
GAK-010 ENSP00000426062 ENST00000510799	H0YA39 [Direct mapping] Cyclin-G-associated kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		255 aa 25.4 kDa	No	0
GAK-011 ENSP00000421049 ENST00000511980	H0Y8H5 [Direct mapping] Cyclin-G-associated kinase Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		467 aa 49 kDa	No	0
GAK-015 ENSP00000422391 ENST00000511229	D6RC24 [Direct mapping] Cyclin-G-associated kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	70 aa 7.8 kDa	No	0
GAK-020 ENSP00000424701 ENST00000502656	D6RAW3 [Direct mapping] Cyclin-G-associated kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	138 aa 15.2 kDa	No	0
GAK-201 ENSP00000484475 ENST00000618573	A0A087X1U9 [Direct mapping] Cyclin-G-associated kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		416 aa 44 kDa	No	0
GAK-202 ENSP00000486984 ENST00000628912	D6RE78 [Direct mapping] Cyclin G associated kinase, isoform CRA_c; Cyclin-G-associated kinase Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	118 aa 12.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.