Tissue expression of GAK - Summary - The Human Protein Atlas

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GAK

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GAK
Gene description	Cyclin G associated kinase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression with a granular pattern in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA027405 , HPA027459 , HPA027463
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GAK (HGNC Symbol)
Synonyms	DNAJC26
Description	Cyclin G associated kinase (HGNC Symbol)
Entrez gene summary	In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	849276 - 932373
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178950 (version 83.38)
Entrez gene	2580
UniProt	O14976 (UniProt - Evidence at protein level)
neXtProt	NX_O14976
Antibodypedia	GAK antibodies

PROTEIN BROWSER

GAK-001	GAK-002	GAK-010	GAK-011	GAK-015	GAK-020	GAK-201	GAK-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GAK-001 ENSP00000314499 ENST00000314167	O14976 [Direct mapping] Cyclin-G-associated kinase Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007030 [Golgi organization] GO:0007049 [cell cycle] GO:0010977 [negative regulation of neuron projection development] GO:0016020 [membrane] GO:0031982 [vesicle] GO:0043231 [intracellular membrane-bounded organelle] GO:0048471 [perinuclear region of cytoplasm] Show all	1311 aa 143.2 kDa	No	0
GAK-002 ENSP00000421361 ENST00000511163	O14976 [Direct mapping] Cyclin-G-associated kinase Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007030 [Golgi organization] GO:0007049 [cell cycle] GO:0010977 [negative regulation of neuron projection development] GO:0016020 [membrane] GO:0031982 [vesicle] GO:0043231 [intracellular membrane-bounded organelle] GO:0048471 [perinuclear region of cytoplasm] Show all	1232 aa 134.5 kDa	No	0
GAK-010 ENSP00000426062 ENST00000510799	H0YA39 [Direct mapping] Cyclin-G-associated kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		255 aa 25.4 kDa	No	0
GAK-011 ENSP00000421049 ENST00000511980	H0Y8H5 [Direct mapping] Cyclin-G-associated kinase Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		467 aa 49 kDa	No	0
GAK-015 ENSP00000422391 ENST00000511229	D6RC24 [Direct mapping] Cyclin-G-associated kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	70 aa 7.8 kDa	No	0
GAK-020 ENSP00000424701 ENST00000502656	D6RAW3 [Direct mapping] Cyclin-G-associated kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	138 aa 15.2 kDa	No	0
GAK-201 ENSP00000484475 ENST00000618573	A0A087X1U9 [Direct mapping] Cyclin-G-associated kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		416 aa 44 kDa	No	0
GAK-202 ENSP00000486984 ENST00000628912	D6RE78 [Direct mapping] Cyclin G associated kinase, isoform CRA_c; Cyclin-G-associated kinase Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	118 aa 12.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.