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Several malignant gliomas showed moderate cytoplasmic immunoreactivity. Seminomas and a few cases of malignant melanomas exhibited moderate nuclear positivity. Remaining malignant cells were in general negative.
GENE INFORMATION
Gene name
MRFAP1 (HGNC Symbol)
Synonyms
PAM14, PGR1
Description
Morf4 family associated protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]