Cell atlas - MRFAP1 - The Human Protein Atlas

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MRFAP1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MRFAP1
Gene description	Morf4 family associated protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA056367
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056367	A549	Nucleus
	HPA056367	MCF7	Nucleus
	HPA056367	U-2 OS	Nucleoplasm	Intensity
	HPA056367	U-2 OS	Cytosol

GENE INFORMATION
Gene name	MRFAP1 (HGNC Symbol)
Synonyms	PAM14, PGR1
Description	Morf4 family associated protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Chromosome	4
Cytoband	p16.1
Chromosome location (bp)	6640091 - 6642745
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179010 (version 83.38)
Entrez gene	93621
UniProt	Q9Y605 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y605
Antibodypedia	MRFAP1 antibodies

PROTEIN BROWSER

MRFAP1-001	MRFAP1-003	MRFAP1-007	MRFAP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRFAP1-001 ENSP00000318352 ENST00000320912	Q9Y605 [Direct mapping] MORF4 family-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0048471 [perinuclear region of cytoplasm] Show all	127 aa 14.6 kDa	No	0
MRFAP1-003 ENSP00000372024 ENST00000382581	Q9Y605 [Direct mapping] MORF4 family-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0048471 [perinuclear region of cytoplasm] Show all	127 aa 14.6 kDa	No	0
MRFAP1-007 ENSP00000422065 ENST00000507420	Q9Y605 [Direct mapping] MORF4 family-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0048471 [perinuclear region of cytoplasm] Show all	127 aa 14.6 kDa	No	0
MRFAP1-201 ENSP00000478229 ENST00000617365	A0A087WTY9 [Direct mapping] MORF4 family-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.