Fields »
ABOUT
HELP
BLOG
PUF60

GENERAL INFORMATION

Gene name

 PUF60

Gene description

 Poly-U binding splicing factor 60KDa

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA052096 , HPA059714
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PUF60 (HGNC Symbol)

Synonyms

 FIR, RoBPI, SIAHBP1

Description

 Poly-U binding splicing factor 60KDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 143816344 - 143829859

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179950 (version 83.38)

Entrez gene

 22827

UniProt

 Q9UHX1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHX1

Antibodypedia

 PUF60 antibodies

PROTEIN BROWSER
«
PUF60-001
PUF60-002
PUF60-003
PUF60-004
PUF60-005
PUF60-006
PUF60-011
PUF60-012
PUF60-013
PUF60-023
PUF60-024
PUF60-025
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PUF60-001
ENSP00000434359
ENST00000526683
Q9UHX1 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0030529 [ribonucleoprotein complex]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
Show all
 559 aa
59.9 kDa 		No 0
PUF60-002
ENSP00000322036
ENST00000349157
Q9UHX1 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0030529 [ribonucleoprotein complex]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
Show all
 542 aa
58.2 kDa 		No 0
PUF60-003
ENSP00000402953
ENST00000453551
Q9UHX1 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0030529 [ribonucleoprotein complex]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
Show all
 516 aa
55.7 kDa 		No 0
PUF60-004
ENSP00000322016
ENST00000313352
Q9UHX1 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0030529 [ribonucleoprotein complex]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
Show all
 499 aa
54 kDa 		No 0
PUF60-005
ENSP00000395417
ENST00000456095
Q9UHX1 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0030529 [ribonucleoprotein complex]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
Show all
 530 aa
57.1 kDa 		No 0
PUF60-006
ENSP00000431960
ENST00000527197
Q9UHX1 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0030529 [ribonucleoprotein complex]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
Show all
 513 aa
55.4 kDa 		No 0
PUF60-011
ENSP00000433403
ENST00000533162
E9PL19 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
Show all
 228 aa
24.8 kDa 		No 0
PUF60-012
ENSP00000434863
ENST00000529999
E9PN18 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
Show all
 263 aa
28.7 kDa 		No 0
PUF60-013
ENSP00000437309
ENST00000531897
E9PMU7 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
Show all
 247 aa
26.9 kDa 		No 0
PUF60-023
ENSP00000432091
ENST00000532884
H0YCP8 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 273 aa
28.1 kDa 		No 0
PUF60-024
ENSP00000432610
ENST00000526459
E9PQ56 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
Show all
 323 aa
34.5 kDa 		No 0
PUF60-025
ENSP00000436131
ENST00000527744
H0YEM1 [Direct mapping]
Poly(U)-binding-splicing factor PUF60
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 336 aa
35.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.