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Few cases of seminomas along with rare thyroid and colorectal cancers showed moderate nuclear positivity. Subset tumor cells in ovarian cancer showed strong nuclear positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
TH (HGNC Symbol)
Synonyms
DYT5b
Description
Tyrosine hydroxylase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)
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GO:0001666 [response to hypoxia] GO:0001963 [synaptic transmission, dopaminergic] GO:0003007 [heart morphogenesis] GO:0004497 [monooxygenase activity] GO:0004511 [tyrosine 3-monooxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005790 [smooth endoplasmic reticulum] GO:0005829 [cytosol] GO:0006585 [dopamine biosynthetic process from tyrosine] GO:0007507 [heart development] GO:0007601 [visual perception] GO:0007612 [learning] GO:0007613 [memory] GO:0007626 [locomotory behavior] GO:0008016 [regulation of heart contraction] GO:0009072 [aromatic amino acid family metabolic process] GO:0009653 [anatomical structure morphogenesis] GO:0009887 [organ morphogenesis] GO:0009898 [cytoplasmic side of plasma membrane] GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen] GO:0019899 [enzyme binding] GO:0031410 [cytoplasmic vesicle] GO:0033162 [melanosome membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042136 [neurotransmitter biosynthetic process] GO:0042416 [dopamine biosynthetic process] GO:0042418 [epinephrine biosynthetic process] GO:0042421 [norepinephrine biosynthetic process] GO:0042423 [catecholamine biosynthetic process] GO:0042462 [eye photoreceptor cell development] GO:0043005 [neuron projection] GO:0043204 [perikaryon] GO:0043473 [pigmentation] GO:0044281 [small molecule metabolic process] GO:0045471 [response to ethanol] GO:0048596 [embryonic camera-type eye morphogenesis] GO:0055114 [oxidation-reduction process]
Enzymes ENZYME proteins Oxidoreductases SCAMPI predicted membrane proteins Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)
Enzymes ENZYME proteins Oxidoreductases SCAMPI predicted membrane proteins Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)
Show all
GO:0001666 [response to hypoxia] GO:0001963 [synaptic transmission, dopaminergic] GO:0003007 [heart morphogenesis] GO:0004497 [monooxygenase activity] GO:0004511 [tyrosine 3-monooxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005790 [smooth endoplasmic reticulum] GO:0005829 [cytosol] GO:0006585 [dopamine biosynthetic process from tyrosine] GO:0007507 [heart development] GO:0007601 [visual perception] GO:0007612 [learning] GO:0007613 [memory] GO:0007626 [locomotory behavior] GO:0008016 [regulation of heart contraction] GO:0009072 [aromatic amino acid family metabolic process] GO:0009653 [anatomical structure morphogenesis] GO:0009887 [organ morphogenesis] GO:0009898 [cytoplasmic side of plasma membrane] GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen] GO:0019899 [enzyme binding] GO:0031410 [cytoplasmic vesicle] GO:0033162 [melanosome membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042136 [neurotransmitter biosynthetic process] GO:0042416 [dopamine biosynthetic process] GO:0042418 [epinephrine biosynthetic process] GO:0042421 [norepinephrine biosynthetic process] GO:0042423 [catecholamine biosynthetic process] GO:0042462 [eye photoreceptor cell development] GO:0043005 [neuron projection] GO:0043204 [perikaryon] GO:0043473 [pigmentation] GO:0044281 [small molecule metabolic process] GO:0045471 [response to ethanol] GO:0048596 [embryonic camera-type eye morphogenesis] GO:0055114 [oxidation-reduction process]
GO:0005506 [iron ion binding] GO:0009072 [aromatic amino acid family metabolic process] GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen] GO:0055114 [oxidation-reduction process]