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TH

GENERAL INFORMATION

Gene name

 TH

Gene description

 Tyrosine hydroxylase

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adrenal gland)
GTEx:Group enriched (adrenal gland, hypothalamus)
FANTOM5:Tissue enhanced (caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in adrenal medulla, peripheral nerve fibers and caudate nucleus.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA061003 , CAB002522 , CAB072340
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION

Gene name

 TH (HGNC Symbol)

Synonyms

 DYT5b

Description

 Tyrosine hydroxylase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 2163929 - 2171877

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180176 (version 83.38)

Entrez gene

 7054

UniProt

 P07101 (UniProt - Evidence at protein level)

neXtProt

 NX_P07101

Antibodypedia

 TH antibodies

PROTEIN BROWSER
TH-001
TH-002
TH-003
TH-005
TH-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TH-001
ENSP00000325951
ENST00000352909
P07101 [Direct mapping]
Tyrosine 3-monooxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0003007 [heart morphogenesis]
GO:0004497 [monooxygenase activity]
GO:0004511 [tyrosine 3-monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006585 [dopamine biosynthetic process from tyrosine]
GO:0007507 [heart development]
GO:0007601 [visual perception]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0007626 [locomotory behavior]
GO:0008016 [regulation of heart contraction]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [organ morphogenesis]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0019899 [enzyme binding]
GO:0031410 [cytoplasmic vesicle]
GO:0033162 [melanosome membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042416 [dopamine biosynthetic process]
GO:0042418 [epinephrine biosynthetic process]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0042462 [eye photoreceptor cell development]
GO:0043005 [neuron projection]
GO:0043204 [perikaryon]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0055114 [oxidation-reduction process]
Show all
 497 aa
55.6 kDa 		No 0
TH-002
ENSP00000370571
ENST00000381178
P07101 [Direct mapping]
Tyrosine 3-monooxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0001975 [response to amphetamine]
GO:0003007 [heart morphogenesis]
GO:0004497 [monooxygenase activity]
GO:0004511 [tyrosine 3-monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006585 [dopamine biosynthetic process from tyrosine]
GO:0006631 [fatty acid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0007507 [heart development]
GO:0007601 [visual perception]
GO:0007605 [sensory perception of sound]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008016 [regulation of heart contraction]
GO:0008021 [synaptic vesicle]
GO:0008198 [ferrous iron binding]
GO:0008199 [ferric iron binding]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0009414 [response to water deprivation]
GO:0009416 [response to light stimulus]
GO:0009635 [response to herbicide]
GO:0009651 [response to salt stress]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [organ morphogenesis]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010038 [response to metal ion]
GO:0010043 [response to zinc ion]
GO:0010259 [multicellular organismal aging]
GO:0014070 [response to organic cyclic compound]
GO:0014823 [response to activity]
GO:0015842 [synaptic vesicle amine transport]
GO:0016137 [glycoside metabolic process]
GO:0016597 [amino acid binding]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0017085 [response to insecticide]
GO:0018963 [phthalate metabolic process]
GO:0019825 [oxygen binding]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0021987 [cerebral cortex development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031667 [response to nutrient levels]
GO:0032355 [response to estradiol]
GO:0032496 [response to lipopolysaccharide]
GO:0033076 [isoquinoline alkaloid metabolic process]
GO:0033162 [melanosome membrane]
GO:0034617 [tetrahydrobiopterin binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035094 [response to nicotine]
GO:0035176 [social behavior]
GO:0035240 [dopamine binding]
GO:0035690 [cellular response to drug]
GO:0035900 [response to isolation stress]
GO:0035902 [response to immobilization stress]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042214 [terpene metabolic process]
GO:0042416 [dopamine biosynthetic process]
GO:0042418 [epinephrine biosynthetic process]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0042462 [eye photoreceptor cell development]
GO:0042493 [response to drug]
GO:0042745 [circadian sleep/wake cycle]
GO:0042755 [eating behavior]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0043204 [perikaryon]
GO:0043434 [response to peptide hormone]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0045472 [response to ether]
GO:0046684 [response to pyrethroid]
GO:0048545 [response to steroid hormone]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0050890 [cognition]
GO:0051412 [response to corticosterone]
GO:0051602 [response to electrical stimulus]
GO:0052314 [phytoalexin metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070848 [response to growth factor]
GO:0071287 [cellular response to manganese ion]
GO:0071312 [cellular response to alkaloid]
GO:0071316 [cellular response to nicotine]
GO:0071333 [cellular response to glucose stimulus]
GO:0071363 [cellular response to growth factor stimulus]
Show all
 528 aa
58.6 kDa 		No 0
TH-003
ENSP00000370567
ENST00000381175
P07101 [Direct mapping]
Tyrosine 3-monooxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0003007 [heart morphogenesis]
GO:0004497 [monooxygenase activity]
GO:0004511 [tyrosine 3-monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006585 [dopamine biosynthetic process from tyrosine]
GO:0007507 [heart development]
GO:0007601 [visual perception]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0007626 [locomotory behavior]
GO:0008016 [regulation of heart contraction]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [organ morphogenesis]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0019899 [enzyme binding]
GO:0031410 [cytoplasmic vesicle]
GO:0033162 [melanosome membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042416 [dopamine biosynthetic process]
GO:0042418 [epinephrine biosynthetic process]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0042462 [eye photoreceptor cell development]
GO:0043005 [neuron projection]
GO:0043204 [perikaryon]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0055114 [oxidation-reduction process]
Show all
 524 aa
58.2 kDa 		No 0
TH-005
ENSP00000403546
ENST00000412076
H0Y677 [Direct mapping]
Tyrosine 3-monooxygenase
Show all
Predicted intracellular proteins
Show all
GO:0005506 [iron ion binding]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0055114 [oxidation-reduction process]
Show all
 116 aa
13 kDa 		No 0
TH-201
ENSP00000328814
ENST00000333684
P07101 [Direct mapping]
Tyrosine 3-monooxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001666 [response to hypoxia]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0003007 [heart morphogenesis]
GO:0004511 [tyrosine 3-monooxygenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006585 [dopamine biosynthetic process from tyrosine]
GO:0007507 [heart development]
GO:0007601 [visual perception]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0007626 [locomotory behavior]
GO:0008016 [regulation of heart contraction]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [organ morphogenesis]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016714 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen]
GO:0019899 [enzyme binding]
GO:0031410 [cytoplasmic vesicle]
GO:0033162 [melanosome membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042416 [dopamine biosynthetic process]
GO:0042418 [epinephrine biosynthetic process]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0042462 [eye photoreceptor cell development]
GO:0043005 [neuron projection]
GO:0043204 [perikaryon]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0055114 [oxidation-reduction process]
Show all
 403 aa
44.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.