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NPLOC4

GENERAL INFORMATION

Gene name

 NPLOC4

Gene description

 NPL4 homolog, ubiquitin recognition factor

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA021560 , HPA023295
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NPLOC4 (HGNC Symbol)

Synonyms

 FLJ20657, KIAA1499, NPL4

Description

 NPL4 homolog, ubiquitin recognition factor (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 81556887 - 81648465

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182446 (version 83.38)

Entrez gene

 55666

UniProt

 Q8TAT6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TAT6

Antibodypedia

 NPLOC4 antibodies

PROTEIN BROWSER
NPLOC4-001
NPLOC4-002
NPLOC4-004
NPLOC4-005
NPLOC4-008
NPLOC4-016
NPLOC4-017
NPLOC4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPLOC4-001
ENSP00000331487
ENST00000331134
Q8TAT6 [Direct mapping]
Nuclear protein localization protein 4 homolog
A0A024R8R4 [Target identity:100%; Query identity:100%]
Nuclear protein localization 4 homolog (S. cerevisiae), isoform CRA_a
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007030 [Golgi organization]
GO:0008270 [zinc ion binding]
GO:0019985 [translesion synthesis]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0036501 [UFD1-NPL4 complex]
GO:0042175 [nuclear outer membrane-endoplasmic reticulum membrane network]
GO:0043130 [ubiquitin binding]
GO:0070987 [error-free translesion synthesis]
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 608 aa
68.1 kDa 		No 0
NPLOC4-002
ENSP00000363879
ENST00000374747
Q8TAT6 [Direct mapping]
Nuclear protein localization protein 4 homolog
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007030 [Golgi organization]
GO:0008270 [zinc ion binding]
GO:0019985 [translesion synthesis]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0036501 [UFD1-NPL4 complex]
GO:0042175 [nuclear outer membrane-endoplasmic reticulum membrane network]
GO:0043130 [ubiquitin binding]
GO:0070987 [error-free translesion synthesis]
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 617 aa
69.5 kDa 		No 0
NPLOC4-004
ENSP00000467400
ENST00000572760
K7EJN1 [Direct mapping]
Nuclear protein localization protein 4 homolog
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043130 [ubiquitin binding]
Show all
 56 aa
5.5 kDa 		No 0
NPLOC4-005
ENSP00000465247
ENST00000573876
K7EJN1 [Direct mapping]
Nuclear protein localization protein 4 homolog
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043130 [ubiquitin binding]
Show all
 56 aa
5.5 kDa 		No 0
NPLOC4-008
ENSP00000458384
ENST00000572824
I3L0W3 [Direct mapping]
Nuclear protein localization protein 4 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043130 [ubiquitin binding]
Show all
 172 aa
18.5 kDa 		No 0
NPLOC4-016
ENSP00000459457
ENST00000573519
I3L281 [Direct mapping]
Nuclear protein localization protein 4 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043130 [ubiquitin binding]
Show all
 145 aa
16.1 kDa 		No 0
NPLOC4-017
ENSP00000460465
ENST00000571714
I3L3I1 [Direct mapping]
Nuclear protein localization protein 4 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043130 [ubiquitin binding]
Show all
 182 aa
20 kDa 		No 0
NPLOC4-201
ENSP00000486640
ENST00000625705
A0A0D9SFI9 [Direct mapping]
Nuclear protein localization protein 4 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043130 [ubiquitin binding]
Show all
 134 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.