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GLUD2

CANCER ATLAS

Gene description

 Glutamate dehydrogenase 2

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA042492
HPA044839

GENE INFORMATION

Gene name

 GLUD2 (HGNC Symbol)

Synonyms

 GLUDP1

Description

 Glutamate dehydrogenase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]

Chromosome

 X

Cytoband

 q24

Chromosome location (bp)

 121047588 - 121050080

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182890 (version 83.38)

Entrez gene

 2747

UniProt

 P49448 (UniProt - Evidence at protein level)

neXtProt

 NX_P49448

Antibodypedia

 GLUD2 antibodies

PROTEIN BROWSER
GLUD2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GLUD2-001
ENSP00000327589
ENST00000328078
P49448 [Direct mapping]
Glutamate dehydrogenase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004352 [glutamate dehydrogenase (NAD+) activity]
GO:0004353 [glutamate dehydrogenase [NAD(P)+] activity]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0006520 [cellular amino acid metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006537 [glutamate biosynthetic process]
GO:0006538 [glutamate catabolic process]
GO:0016491 [oxidoreductase activity]
GO:0043531 [ADP binding]
GO:0055114 [oxidation-reduction process]
GO:0070728 [leucine binding]
Show all
 558 aa
61.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.