Cell atlas - GLUD2 - The Human Protein Atlas

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GLUD2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	GLUD2
Gene description	Glutamate dehydrogenase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (WM-115, SK-MEL-30, K-562)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA044839 , HPA061369
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (WM-115, SK-MEL-30, K-562) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044839	A-431	Mitochondria
	HPA044839	U-2 OS	Mitochondria
	HPA044839	U-251 MG	Mitochondria
	HPA061369	CACO-2	Mitochondria
	HPA061369	Hep G2	Mitochondria
	HPA061369	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	GLUD2 (HGNC Symbol)
Synonyms	GLUDP1
Description	Glutamate dehydrogenase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband	q24
Chromosome location (bp)	121047588 - 121050080
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182890 (version 83.38)
Entrez gene	2747
UniProt	P49448 (UniProt - Evidence at protein level)
neXtProt	NX_P49448
Antibodypedia	GLUD2 antibodies

PROTEIN BROWSER

GLUD2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLUD2-001 ENSP00000327589 ENST00000328078	P49448 [Direct mapping] Glutamate dehydrogenase 2, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004352 [glutamate dehydrogenase (NAD+) activity] GO:0004353 [glutamate dehydrogenase [NAD(P)+] activity] GO:0005525 [GTP binding] GO:0005739 [mitochondrion] GO:0006520 [cellular amino acid metabolic process] GO:0006536 [glutamate metabolic process] GO:0006537 [glutamate biosynthetic process] GO:0006538 [glutamate catabolic process] GO:0016491 [oxidoreductase activity] GO:0043531 [ADP binding] GO:0055114 [oxidation-reduction process] GO:0070728 [leucine binding] Show all	558 aa 61.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.