Expression of CCBE1 in cancer - Summary

CANCER ATLAS

Gene description

Collagen and calcium binding EGF domains 1

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041361	HPA041374

GENE INFORMATION
Gene name	CCBE1 (HGNC Symbol)
Synonyms	FLJ30681, KIAA1983
Description	Collagen and calcium binding EGF domains 1 (HGNC Symbol)
Entrez gene summary	This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010]
Chromosome	18
Cytoband	q21.32
Chromosome location (bp)	59430940 - 59697380
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183287 (version 83.38)
Entrez gene	147372
UniProt	Q6UXH8 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UXH8
Antibodypedia	CCBE1 antibodies

PROTEIN BROWSER

CCBE1-001	CCBE1-004	CCBE1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCBE1-001 ENSP00000404464 ENST00000439986	Q6UXH8 [Direct mapping] Collagen and calcium-binding EGF domain-containing protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Show all	GO:0001946 [lymphangiogenesis] GO:0002020 [protease binding] GO:0002040 [sprouting angiogenesis] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010595 [positive regulation of endothelial cell migration] GO:0010954 [positive regulation of protein processing] GO:0045766 [positive regulation of angiogenesis] GO:0048845 [venous blood vessel morphogenesis] GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway] GO:1901492 [positive regulation of lymphangiogenesis] Show all	406 aa 44.1 kDa	Yes	0
CCBE1-004 ENSP00000467710 ENST00000589419	K7EQ81 [Direct mapping] Collagen and calcium-binding EGF domain-containing protein 1 Show all	Predicted intracellular proteins Show all		46 aa 5.1 kDa	No	0
CCBE1-201 ENSP00000381241 ENST00000398179	A0A0A0MS88 [Direct mapping] Collagen and calcium-binding EGF domain-containing protein 1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	336 aa 36.5 kDa	No	0