Tissue expression of CCBE1 - Summary - The Human Protein Atlas

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CCBE1

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CCBE1
Gene description	Collagen and calcium binding EGF domains 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (ovary)
GTEx:	Tissue enhanced (ovary)
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA041361 , HPA041374
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (ovary)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (ovary)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	CCBE1 (HGNC Symbol)
Synonyms	FLJ30681, KIAA1983
Description	Collagen and calcium binding EGF domains 1 (HGNC Symbol)
Entrez gene summary	This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010]
Chromosome	18
Cytoband	q21.32
Chromosome location (bp)	59430940 - 59697380
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183287 (version 83.38)
Entrez gene	147372
UniProt	Q6UXH8 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UXH8
Antibodypedia	CCBE1 antibodies

PROTEIN BROWSER

CCBE1-001	CCBE1-004	CCBE1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCBE1-001 ENSP00000404464 ENST00000439986	Q6UXH8 [Direct mapping] Collagen and calcium-binding EGF domain-containing protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Show all	GO:0001946 [lymphangiogenesis] GO:0002020 [protease binding] GO:0002040 [sprouting angiogenesis] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010595 [positive regulation of endothelial cell migration] GO:0010954 [positive regulation of protein processing] GO:0045766 [positive regulation of angiogenesis] GO:0048845 [venous blood vessel morphogenesis] GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway] GO:1901492 [positive regulation of lymphangiogenesis] Show all	406 aa 44.1 kDa	Yes	0
CCBE1-004 ENSP00000467710 ENST00000589419	K7EQ81 [Direct mapping] Collagen and calcium-binding EGF domain-containing protein 1 Show all	Predicted intracellular proteins Show all		46 aa 5.1 kDa	No	0
CCBE1-201 ENSP00000381241 ENST00000398179	A0A0A0MS88 [Direct mapping] Collagen and calcium-binding EGF domain-containing protein 1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	336 aa 36.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.