Cell atlas - CCBE1 - The Human Protein Atlas

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CCBE1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CCBE1
Gene description	Collagen and calcium binding EGF domains 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol.
RNA cell category	Cell line enhanced (LHCN-M2, HBF TERT88, BJ hTERT+ SV40 Large T+ RasG12V, BJ, BJ hTERT+, TIME)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (validated), Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA041361 , HPA041374
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (LHCN-M2, HBF TERT88, BJ hTERT+ SV40 Large T+ RasG12V, BJ, BJ hTERT+, TIME) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol.

Main location

Plasma membrane (validated), Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041361	A-431	Cytosol
	HPA041361	U-2 OS	Plasma membrane
	HPA041361	U-2 OS	Cytosol
	HPA041374	A-431	Plasma membrane
	HPA041374	A-431	Cytosol
	HPA041374	U-2 OS	Nucleoli
			Plasma membrane
			Cytosol
	HPA041374	U-251 MG	Plasma membrane
	HPA041374	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CCBE1 (HGNC Symbol)
Synonyms	FLJ30681, KIAA1983
Description	Collagen and calcium binding EGF domains 1 (HGNC Symbol)
Entrez gene summary	This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010]
Chromosome	18
Cytoband	q21.32
Chromosome location (bp)	59430940 - 59697380
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183287 (version 83.38)
Entrez gene	147372
UniProt	Q6UXH8 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UXH8
Antibodypedia	CCBE1 antibodies

PROTEIN BROWSER

CCBE1-001	CCBE1-004	CCBE1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCBE1-001 ENSP00000404464 ENST00000439986	Q6UXH8 [Direct mapping] Collagen and calcium-binding EGF domain-containing protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Show all	GO:0001946 [lymphangiogenesis] GO:0002020 [protease binding] GO:0002040 [sprouting angiogenesis] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010595 [positive regulation of endothelial cell migration] GO:0010954 [positive regulation of protein processing] GO:0045766 [positive regulation of angiogenesis] GO:0048845 [venous blood vessel morphogenesis] GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway] GO:1901492 [positive regulation of lymphangiogenesis] Show all	406 aa 44.1 kDa	Yes	0
CCBE1-004 ENSP00000467710 ENST00000589419	K7EQ81 [Direct mapping] Collagen and calcium-binding EGF domain-containing protein 1 Show all	Predicted intracellular proteins Show all		46 aa 5.1 kDa	No	0
CCBE1-201 ENSP00000381241 ENST00000398179	A0A0A0MS88 [Direct mapping] Collagen and calcium-binding EGF domain-containing protein 1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	336 aa 36.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.