Cell atlas - ARSI - The Human Protein Atlas

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ARSI

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	ARSI
Gene description	Arylsulfatase family, member I
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (U-87 MG, HaCaT)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA038386
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG, HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038386	Hep G2	Golgi apparatus	Intensity
	HPA038386	U-2 OS	No staining
	HPA038386	U-251 MG	No staining

GENE INFORMATION
Gene name	ARSI (HGNC Symbol)
Synonyms	FLJ16069, SPG66
Description	Arylsulfatase family, member I (HGNC Symbol)
Entrez gene summary	Sulfatases (EC 3.1.5.6), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Chromosome	5
Cytoband	q32
Chromosome location (bp)	150296343 - 150339307
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183876 (version 83.38)
Entrez gene	340075
UniProt	Q5FYB1 (UniProt - Evidence at protein level)
neXtProt	NX_Q5FYB1
Antibodypedia	ARSI antibodies

PROTEIN BROWSER

ARSI-001	ARSI-002	ARSI-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARSI-001 ENSP00000333395 ENST00000328668	Q5FYB1 [Direct mapping] Arylsulfatase I Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004065 [arylsulfatase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005788 [endoplasmic reticulum lumen] GO:0006665 [sphingolipid metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	569 aa 64 kDa	Yes	0
ARSI-002 ENSP00000426879 ENST00000515301	Q5FYB1 [Direct mapping] Arylsulfatase I Show all	Predicted intracellular proteins Show all	GO:0003824 [catalytic activity] GO:0004065 [arylsulfatase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005788 [endoplasmic reticulum lumen] GO:0006665 [sphingolipid metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	426 aa 48.3 kDa	No	0
ARSI-003 ENSP00000420955 ENST00000509146	D6RDH0 [Direct mapping] Arylsulfatase I Show all	Predicted intracellular proteins Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] Show all	86 aa 9.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.