Tissue expression of ARSI - Summary - The Human Protein Atlas

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ARSI

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ARSI
Gene description	Arylsulfatase family, member I
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining in cells/structures not annotated, view images. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA038386 , HPA038398
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION
Gene name	ARSI (HGNC Symbol)
Synonyms	FLJ16069, SPG66
Description	Arylsulfatase family, member I (HGNC Symbol)
Entrez gene summary	Sulfatases (EC 3.1.5.6), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Chromosome	5
Cytoband	q32
Chromosome location (bp)	150296343 - 150339307
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183876 (version 83.38)
Entrez gene	340075
UniProt	Q5FYB1 (UniProt - Evidence at protein level)
neXtProt	NX_Q5FYB1
Antibodypedia	ARSI antibodies

PROTEIN BROWSER

ARSI-001	ARSI-002	ARSI-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARSI-001 ENSP00000333395 ENST00000328668	Q5FYB1 [Direct mapping] Arylsulfatase I Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004065 [arylsulfatase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005788 [endoplasmic reticulum lumen] GO:0006665 [sphingolipid metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	569 aa 64 kDa	Yes	0
ARSI-002 ENSP00000426879 ENST00000515301	Q5FYB1 [Direct mapping] Arylsulfatase I Show all	Predicted intracellular proteins Show all	GO:0003824 [catalytic activity] GO:0004065 [arylsulfatase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005788 [endoplasmic reticulum lumen] GO:0006665 [sphingolipid metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	426 aa 48.3 kDa	No	0
ARSI-003 ENSP00000420955 ENST00000509146	D6RDH0 [Direct mapping] Arylsulfatase I Show all	Predicted intracellular proteins Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] Show all	86 aa 9.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.