Cell atlas - SIX6 - The Human Protein Atlas

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SIX6

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SIX6
Gene description	SIX homeobox 6
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enriched (MOLT-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001403
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (MOLT-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001403	A-431	Nucleoplasm
	HPA001403	SH-SY5Y	Nucleoplasm
	HPA001403	U-2 OS	No staining

GENE INFORMATION
Gene name	SIX6 (HGNC Symbol)
Synonyms	OPTX2, Six9
Description	SIX homeobox 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q23.1
Chromosome location (bp)	60508951 - 60512850
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184302 (version 83.38)
Entrez gene	4990
UniProt	O95475 (UniProt - Evidence at protein level)
neXtProt	NX_O95475
Antibodypedia	SIX6 antibodies

PROTEIN BROWSER

SIX6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIX6-001 ENSP00000328596 ENST00000327720	O95475 [Direct mapping] Homeobox protein SIX6 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007601 [visual perception] GO:0009887 [organ morphogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	246 aa 27.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.