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SIX6

GENERAL INFORMATION

Gene name

 SIX6

Gene description

 SIX homeobox 6

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Tissue enriched (pituitary gland)
FANTOM5:Tissue enriched (pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in retina and pituitary gland.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
HPA001403
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION

Gene name

 SIX6 (HGNC Symbol)

Synonyms

 OPTX2, Six9

Description

 SIX homeobox 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q23.1

Chromosome location (bp)

 60508951 - 60512850

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184302 (version 83.38)

Entrez gene

 4990

UniProt

 O95475 (UniProt - Evidence at protein level)

neXtProt

 NX_O95475

Antibodypedia

 SIX6 antibodies

PROTEIN BROWSER
SIX6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIX6-001
ENSP00000328596
ENST00000327720
O95475 [Direct mapping]
Homeobox protein SIX6
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007601 [visual perception]
GO:0009887 [organ morphogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 246 aa
27.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.