Expression of SLITRK6 in cancer - Summary

CANCER ATLAS

Gene description

SLIT and NTRK-like family, member 6

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014491

GENE INFORMATION
Gene name	SLITRK6 (HGNC Symbol)
Synonyms	FLJ22774
Description	SLIT and NTRK-like family, member 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness. [provided by RefSeq, Dec 2014]
Chromosome	13
Cytoband	q31.1
Chromosome location (bp)	85792790 - 85799488
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184564 (version 83.38)
Entrez gene	84189
UniProt	Q9H5Y7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H5Y7
Antibodypedia	SLITRK6 antibodies

PROTEIN BROWSER

SLITRK6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLITRK6-001 ENSP00000383143 ENST00000400286	Q9H5Y7 [Direct mapping] SLIT and NTRK-like protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001964 [startle response] GO:0002088 [lens development in camera-type eye] GO:0002093 [auditory receptor cell morphogenesis] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007409 [axonogenesis] GO:0007416 [synapse assembly] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0008344 [adult locomotory behavior] GO:0009986 [cell surface] GO:0021562 [vestibulocochlear nerve development] GO:0031223 [auditory behavior] GO:0035264 [multicellular organism growth] GO:0042472 [inner ear morphogenesis] GO:0043010 [camera-type eye development] GO:0048812 [neuron projection morphogenesis] GO:0051965 [positive regulation of synapse assembly] GO:0060005 [vestibular reflex] GO:0060007 [linear vestibuloocular reflex] GO:0060384 [innervation] GO:0071944 [cell periphery] GO:0090102 [cochlea development] Show all	841 aa 95.1 kDa	Yes	1