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SLITRK6

GENERAL INFORMATION

Gene name

 SLITRK6

Gene description

 SLIT and NTRK-like family, member 6

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (urinary bladder)
GTEx:Group enriched (urinary bladder, salivary gland)
FANTOM5:Tissue enhanced (urinary bladder, prostate)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA014491
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (urinary bladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (urinary bladder, salivary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (urinary bladder, prostate)

GENE INFORMATION

Gene name

 SLITRK6 (HGNC Symbol)

Synonyms

 FLJ22774

Description

 SLIT and NTRK-like family, member 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness. [provided by RefSeq, Dec 2014]

Chromosome

 13

Cytoband

 q31.1

Chromosome location (bp)

 85792790 - 85799488

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184564 (version 83.38)

Entrez gene

 84189

UniProt

 Q9H5Y7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9H5Y7

Antibodypedia

 SLITRK6 antibodies

PROTEIN BROWSER
SLITRK6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLITRK6-001
ENSP00000383143
ENST00000400286
Q9H5Y7 [Direct mapping]
SLIT and NTRK-like protein 6
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0001964 [startle response]
GO:0002088 [lens development in camera-type eye]
GO:0002093 [auditory receptor cell morphogenesis]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0007409 [axonogenesis]
GO:0007416 [synapse assembly]
GO:0007601 [visual perception]
GO:0007605 [sensory perception of sound]
GO:0008344 [adult locomotory behavior]
GO:0009986 [cell surface]
GO:0021562 [vestibulocochlear nerve development]
GO:0031223 [auditory behavior]
GO:0035264 [multicellular organism growth]
GO:0042472 [inner ear morphogenesis]
GO:0043010 [camera-type eye development]
GO:0048812 [neuron projection morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
GO:0060005 [vestibular reflex]
GO:0060007 [linear vestibuloocular reflex]
GO:0060384 [innervation]
GO:0071944 [cell periphery]
GO:0090102 [cochlea development]
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 841 aa
95.1 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.