Tissue expression of SEPT9 - Summary - The Human Protein Atlas

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SEPT9

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SEPT9
Gene description	Septin 9
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	34
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic and occasional membrane expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA042564
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SEPT9 (HGNC Symbol)
Synonyms	AF17q25, KIAA0991, MSF, MSF1, PNUTL4, SeptD1
Description	Septin 9 (HGNC Symbol)
Entrez gene summary	This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2009]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	77280569 - 77500596
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184640 (version 83.38)
Entrez gene	10801
UniProt	Q9UHD8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHD8
Antibodypedia	SEPT9 antibodies

PROTEIN BROWSER

SEPT9-001	SEPT9-004	SEPT9-006	SEPT9-008	SEPT9-009	SEPT9-010	SEPT9-011	SEPT9-012	SEPT9-013	SEPT9-014	SEPT9-015	SEPT9-016	SEPT9-024	SEPT9-027	SEPT9-028	SEPT9-030	SEPT9-034	SEPT9-040	SEPT9-042	SEPT9-043	SEPT9-045	SEPT9-047	SEPT9-048	SEPT9-049	SEPT9-050	SEPT9-051	SEPT9-052	SEPT9-054	SEPT9-055	SEPT9-060	SEPT9-062	SEPT9-063	SEPT9-201	SEPT9-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEPT9-001 ENSP00000391249 ENST00000427177	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	586 aa 65.4 kDa	No	0
SEPT9-004 ENSP00000406987 ENST00000431235	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	422 aa 47.5 kDa	No	0
SEPT9-006 ENSP00000465464 ENST00000590294	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	568 aa 63.7 kDa	No	0
SEPT9-008 ENSP00000405877 ENST00000423034	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	579 aa 64.7 kDa	No	0
SEPT9-009 ENSP00000403194 ENST00000427674	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	422 aa 47.5 kDa	No	0
SEPT9-010 ENSP00000467051 ENST00000592420	K7EJL9 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0015629 [actin cytoskeleton] Show all	189 aa 20 kDa	No	0
SEPT9-011 ENSP00000468120 ENST00000585930	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	362 aa 41.2 kDa	Yes	0
SEPT9-012 ENSP00000438089 ENST00000541152	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	335 aa 38.5 kDa	No	0
SEPT9-013 ENSP00000466648 ENST00000592951	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	335 aa 38.5 kDa	No	0
SEPT9-014 ENSP00000466247 ENST00000591088	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	335 aa 38.5 kDa	No	0
SEPT9-015 ENSP00000415624 ENST00000427180	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	474 aa 52.9 kDa	No	0
SEPT9-016 ENSP00000468406 ENST00000591198	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	567 aa 63.5 kDa	No	0
SEPT9-024 ENSP00000465332 ENST00000589070	K7EJV0 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		125 aa 13.7 kDa	No	0
SEPT9-027 ENSP00000465026 ENST00000590595	K7EJ51 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	134 aa 14.5 kDa	No	0
SEPT9-028 ENSP00000468504 ENST00000591934	K7EPY1 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0015629 [actin cytoskeleton] Show all	151 aa 16.4 kDa	No	0
SEPT9-030 ENSP00000466164 ENST00000590059	K7ER14 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0015629 [actin cytoskeleton] Show all	159 aa 17.1 kDa	No	0
SEPT9-034 ENSP00000466997 ENST00000589140	K7ENL0 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0015629 [actin cytoskeleton] Show all	152 aa 16.7 kDa	No	0
SEPT9-040 ENSP00000467908 ENST00000591020	K7EIE4 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	157 aa 18 kDa	No	0
SEPT9-042 ENSP00000464832 ENST00000588958	K7EL40 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	209 aa 24 kDa	No	0
SEPT9-043 ENSP00000467792 ENST00000586128	K7EN52 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	116 aa 12.8 kDa	No	0
SEPT9-045 ENSP00000465415 ENST00000591704	K7EK18 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	195 aa 22.2 kDa	No	0
SEPT9-047 ENSP00000466201 ENST00000590938	K7EJZ2 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	135 aa 15.2 kDa	No	0
SEPT9-048 ENSP00000468110 ENST00000586433	K7ER52 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	151 aa 17.3 kDa	No	0
SEPT9-049 ENSP00000467780 ENST00000585929	K7EQD7 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	165 aa 18.9 kDa	No	0
SEPT9-050 ENSP00000467619 ENST00000590917	K7EQ08 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	57 aa 6.4 kDa	No	0
SEPT9-051 ENSP00000468410 ENST00000591472	K7ENQ5 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	127 aa 14.2 kDa	No	0
SEPT9-052 ENSP00000465904 ENST00000593189	K7EL40 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	209 aa 24 kDa	No	0
SEPT9-054 ENSP00000466170 ENST00000586521	K7EKN4 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	108 aa 12.1 kDa	No	0
SEPT9-055 ENSP00000466532 ENST00000589920	K7EIR4 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	104 aa 11.6 kDa	No	0
SEPT9-060 ENSP00000468668 ENST00000588690	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	422 aa 47.5 kDa	No	0
SEPT9-062 ENSP00000468244 ENST00000590825	K7ERG1 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	35 aa 3.7 kDa	No	0
SEPT9-063 ENSP00000466115 ENST00000585638	K7ELJ9 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	144 aa 16.4 kDa	No	0
SEPT9-201 ENSP00000329161 ENST00000329047	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	568 aa 63.7 kDa	No	0
SEPT9-202 ENSP00000400181 ENST00000449803	Q9UHD8 [Direct mapping] Septin-9 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0007049 [cell cycle] GO:0015629 [actin cytoskeleton] GO:0048471 [perinuclear region of cytoplasm] GO:0051291 [protein heterooligomerization] GO:0051301 [cell division] Show all	422 aa 47.5 kDa	No	0

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