Expression of SLC24A3 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043400	HPA045497

GENE INFORMATION
Gene name	SLC24A3
Synonyms
Description	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 (HGNC Symbol)
Entrez gene summary	Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]
Chromosome	20
Cytoband	p11.23
Chromosome location (bp)	19212646 - 19722937
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185052 (version 83.38)
Entrez gene	57419
UniProt	Q9HC58 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9HC58
Antibodypedia	SLC24A3 antibodies

PROTEIN BROWSER

SLC24A3-001	SLC24A3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC24A3-001 ENSP00000333519 ENST00000328041	Q9HC58 [Direct mapping] Sodium/potassium/calcium exchanger 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	644 aa 72 kDa	No	>9
SLC24A3-201 ENSP00000482967 ENST00000613834	Q9HC58 [Direct mapping] Sodium/potassium/calcium exchanger 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	644 aa 72 kDa	No	>9