Cell atlas - SLC24A3 - The Human Protein Atlas

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SLC24A3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SLC24A3
Gene description	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (HMC-1, HEL, T-47d)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, HEL, T-47d) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SLC24A3
Synonyms
Description	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 (HGNC Symbol)
Entrez gene summary	Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]
Chromosome	20
Cytoband	p11.23
Chromosome location (bp)	19212646 - 19722937
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185052 (version 83.38)
Entrez gene	57419
UniProt	Q9HC58 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9HC58
Antibodypedia	SLC24A3 antibodies

PROTEIN BROWSER

SLC24A3-001	SLC24A3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC24A3-001 ENSP00000333519 ENST00000328041	Q9HC58 [Direct mapping] Sodium/potassium/calcium exchanger 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	644 aa 72 kDa	No	>9
SLC24A3-201 ENSP00000482967 ENST00000613834	Q9HC58 [Direct mapping] Sodium/potassium/calcium exchanger 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	644 aa 72 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.