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SLC24A3

GENERAL INFORMATION

Gene name

 SLC24A3

Gene description

 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA043400 , HPA045497
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 SLC24A3

Synonyms

Description

 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 (HGNC Symbol)

Entrez gene summary

 Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]

Chromosome

 20

Cytoband

 p11.23

Chromosome location (bp)

 19212646 - 19722937

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185052 (version 83.38)

Entrez gene

 57419

UniProt

 Q9HC58 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9HC58

Antibodypedia

 SLC24A3 antibodies

PROTEIN BROWSER
SLC24A3-001
SLC24A3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC24A3-001
ENSP00000333519
ENST00000328041
Q9HC58 [Direct mapping]
Sodium/potassium/calcium exchanger 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0015293 [symporter activity]
GO:0016021 [integral component of membrane]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
 644 aa
72 kDa 		No >9
SLC24A3-201
ENSP00000482967
ENST00000613834
Q9HC58 [Direct mapping]
Sodium/potassium/calcium exchanger 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0015293 [symporter activity]
GO:0016021 [integral component of membrane]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
 644 aa
72 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.