Cell atlas - ANKFY1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ANKFY1

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Endosomes

Human cell
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ANKFY1
Gene description	Ankyrin repeat and FYVE domain containing 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endosomes (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA024522 , HPA065849
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endosome.

Main location

Endosomes (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024522	A549	Vesicles
	HPA024522	U-2 OS	Vesicles
	HPA065849	A549	Endosomes
	HPA065849	HEK 293	Endosomes
	HPA065849	U-2 OS	Endosomes

CUSTOM DATA


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA065849	U-2 OS	Image	ANKFY1 localizes to endosomes, as it co-localizes with the endosomal marker EEA1.


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA065849	U-2 OS	Image	ANKFY1 localizes to a subcompartment of retromers, as it does not completely co-localizes with the retromer marker VPS26A in a retromer.

GENE INFORMATION
Gene name	ANKFY1 (HGNC Symbol)
Synonyms	ANKHZN, BTBD23, KIAA1255, RANK-5, ZFYVE14
Description	Ankyrin repeat and FYVE domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle or protein transport. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Apr 2012]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4163907 - 4263977
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185722 (version 83.38)
Entrez gene	51479
UniProt	Q9P2R3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2R3
Antibodypedia	ANKFY1 antibodies

PROTEIN BROWSER

ANKFY1-001	ANKFY1-003	ANKFY1-008	ANKFY1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKFY1-001 ENSP00000459943 ENST00000570535	Q9P2R3 [Direct mapping] Rabankyrin-5 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0006897 [endocytosis] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0017137 [Rab GTPase binding] GO:0030904 [retromer complex] GO:0032439 [endosome localization] GO:0034058 [endosomal vesicle fusion] GO:0042147 [retrograde transport, endosome to Golgi] GO:0044354 [macropinosome] GO:0046872 [metal ion binding] GO:0048549 [positive regulation of pinocytosis] GO:0070062 [extracellular exosome] GO:0090160 [Golgi to lysosome transport] GO:1901981 [phosphatidylinositol phosphate binding] Show all	1211 aa 132.8 kDa	No	0
ANKFY1-003 ENSP00000459775 ENST00000574367	Q9P2R3 [Direct mapping] Rabankyrin-5 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0006897 [endocytosis] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0017137 [Rab GTPase binding] GO:0030904 [retromer complex] GO:0032439 [endosome localization] GO:0034058 [endosomal vesicle fusion] GO:0042147 [retrograde transport, endosome to Golgi] GO:0044354 [macropinosome] GO:0046872 [metal ion binding] GO:0048549 [positive regulation of pinocytosis] GO:0070062 [extracellular exosome] GO:0090160 [Golgi to lysosome transport] GO:1901981 [phosphatidylinositol phosphate binding] Show all	1170 aa 128.5 kDa	No	0
ANKFY1-008 ENSP00000343362 ENST00000341657	Q9P2R3 [Direct mapping] Rabankyrin-5 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0006897 [endocytosis] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0017137 [Rab GTPase binding] GO:0030904 [retromer complex] GO:0032439 [endosome localization] GO:0034058 [endosomal vesicle fusion] GO:0042147 [retrograde transport, endosome to Golgi] GO:0044354 [macropinosome] GO:0046872 [metal ion binding] GO:0048549 [positive regulation of pinocytosis] GO:0070062 [extracellular exosome] GO:0090160 [Golgi to lysosome transport] GO:1901981 [phosphatidylinositol phosphate binding] Show all	1169 aa 128.4 kDa	No	0
ANKFY1-012 ENSP00000459247 ENST00000574736	I3L1Z9 [Direct mapping] Rabankyrin-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		60 aa 6.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.