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ANKFY1

GENERAL INFORMATION

Gene name

 ANKFY1

Gene description

 Ankyrin repeat and FYVE domain containing 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, highest levels in gastrointestinal tract and neurons in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA024513 , HPA024522
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ANKFY1 (HGNC Symbol)

Synonyms

 ANKHZN, BTBD23, KIAA1255, RANK-5, ZFYVE14

Description

 Ankyrin repeat and FYVE domain containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle or protein transport. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Apr 2012]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4163907 - 4263977

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185722 (version 83.38)

Entrez gene

 51479

UniProt

 Q9P2R3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P2R3

Antibodypedia

 ANKFY1 antibodies

PROTEIN BROWSER
ANKFY1-001
ANKFY1-003
ANKFY1-008
ANKFY1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANKFY1-001
ENSP00000459943
ENST00000570535
Q9P2R3 [Direct mapping]
Rabankyrin-5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0006897 [endocytosis]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0017137 [Rab GTPase binding]
GO:0030904 [retromer complex]
GO:0032439 [endosome localization]
GO:0034058 [endosomal vesicle fusion]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0044354 [macropinosome]
GO:0046872 [metal ion binding]
GO:0048549 [positive regulation of pinocytosis]
GO:0070062 [extracellular exosome]
GO:0090160 [Golgi to lysosome transport]
GO:1901981 [phosphatidylinositol phosphate binding]
Show all
 1211 aa
132.8 kDa 		No 0
ANKFY1-003
ENSP00000459775
ENST00000574367
Q9P2R3 [Direct mapping]
Rabankyrin-5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0006897 [endocytosis]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0017137 [Rab GTPase binding]
GO:0030904 [retromer complex]
GO:0032439 [endosome localization]
GO:0034058 [endosomal vesicle fusion]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0044354 [macropinosome]
GO:0046872 [metal ion binding]
GO:0048549 [positive regulation of pinocytosis]
GO:0070062 [extracellular exosome]
GO:0090160 [Golgi to lysosome transport]
GO:1901981 [phosphatidylinositol phosphate binding]
Show all
 1170 aa
128.5 kDa 		No 0
ANKFY1-008
ENSP00000343362
ENST00000341657
Q9P2R3 [Direct mapping]
Rabankyrin-5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0006897 [endocytosis]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0017137 [Rab GTPase binding]
GO:0030904 [retromer complex]
GO:0032439 [endosome localization]
GO:0034058 [endosomal vesicle fusion]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0044354 [macropinosome]
GO:0046872 [metal ion binding]
GO:0048549 [positive regulation of pinocytosis]
GO:0070062 [extracellular exosome]
GO:0090160 [Golgi to lysosome transport]
GO:1901981 [phosphatidylinositol phosphate binding]
Show all
 1169 aa
128.4 kDa 		No 0
ANKFY1-012
ENSP00000459247
ENST00000574736
I3L1Z9 [Direct mapping]
Rabankyrin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 60 aa
6.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.