Cell atlas - AMTN - The Human Protein Atlas

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AMTN

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	AMTN
Gene description	Amelotin
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (MCF7)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MCF7) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	AMTN (HGNC Symbol)
Synonyms	RSTI689, UNQ689
Description	Amelotin (HGNC Symbol)
Entrez gene summary	The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	70518540 - 70532742
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187689 (version 83.38)
Entrez gene	401138
UniProt	Q6UX39 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UX39
Antibodypedia	AMTN antibodies

PROTEIN BROWSER

AMTN-001	AMTN-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMTN-001 ENSP00000341013 ENST00000339336	Q6UX39 [Direct mapping] Amelotin F1T0L8 [Target identity:100%; Query identity:100%] Amelotin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003674 [molecular_function] GO:0005578 [proteinaceous extracellular matrix] GO:0005605 [basal lamina] GO:0005911 [cell-cell junction] GO:0007155 [cell adhesion] GO:0031214 [biomineral tissue development] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0070169 [positive regulation of biomineral tissue development] GO:0070175 [positive regulation of enamel mineralization] Show all	209 aa 21.6 kDa	Yes	0
AMTN-002 ENSP00000422452 ENST00000504451	Q6UX39 [Direct mapping] Amelotin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003674 [molecular_function] GO:0005578 [proteinaceous extracellular matrix] GO:0005605 [basal lamina] GO:0005911 [cell-cell junction] GO:0007155 [cell adhesion] GO:0031214 [biomineral tissue development] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0070169 [positive regulation of biomineral tissue development] Show all	208 aa 21.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.