Tissue expression of AMTN - Summary - The Human Protein Atlas

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AMTN

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	AMTN
Gene description	Amelotin
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (tonsil, stomach)
GTEx:	Tissue enriched (salivary gland)
FANTOM5:	Tissue enriched (tonsil)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External data suggests involvement in amelogenesis.
Reliability score	Uncertain based on 2 antibodies. HPA036136 , HPA036137
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

Small intestine

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (tonsil, stomach)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (tonsil)

GENE INFORMATION
Gene name	AMTN (HGNC Symbol)
Synonyms	RSTI689, UNQ689
Description	Amelotin (HGNC Symbol)
Entrez gene summary	The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	70518540 - 70532742
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187689 (version 83.38)
Entrez gene	401138
UniProt	Q6UX39 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UX39
Antibodypedia	AMTN antibodies

PROTEIN BROWSER

AMTN-001	AMTN-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMTN-001 ENSP00000341013 ENST00000339336	Q6UX39 [Direct mapping] Amelotin F1T0L8 [Target identity:100%; Query identity:100%] Amelotin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003674 [molecular_function] GO:0005578 [proteinaceous extracellular matrix] GO:0005605 [basal lamina] GO:0005911 [cell-cell junction] GO:0007155 [cell adhesion] GO:0031214 [biomineral tissue development] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0070169 [positive regulation of biomineral tissue development] GO:0070175 [positive regulation of enamel mineralization] Show all	209 aa 21.6 kDa	Yes	0
AMTN-002 ENSP00000422452 ENST00000504451	Q6UX39 [Direct mapping] Amelotin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003674 [molecular_function] GO:0005578 [proteinaceous extracellular matrix] GO:0005605 [basal lamina] GO:0005911 [cell-cell junction] GO:0007155 [cell adhesion] GO:0031214 [biomineral tissue development] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0070169 [positive regulation of biomineral tissue development] Show all	208 aa 21.5 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.