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AMTN

CANCER ATLAS

Gene description

 Amelotin

Protein class

 Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036136
HPA036137

GENE INFORMATION

Gene name

 AMTN (HGNC Symbol)

Synonyms

 RSTI689, UNQ689

Description

 Amelotin (HGNC Symbol)

Entrez gene summary

 The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 70518540 - 70532742

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187689 (version 83.38)

Entrez gene

 401138

UniProt

 Q6UX39 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6UX39

Antibodypedia

 AMTN antibodies

PROTEIN BROWSER
AMTN-001
AMTN-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AMTN-001
ENSP00000341013
ENST00000339336
Q6UX39 [Direct mapping]
Amelotin
F1T0L8 [Target identity:100%; Query identity:100%]
Amelotin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0003674 [molecular_function]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005605 [basal lamina]
GO:0005911 [cell-cell junction]
GO:0007155 [cell adhesion]
GO:0031214 [biomineral tissue development]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0070169 [positive regulation of biomineral tissue development]
GO:0070175 [positive regulation of enamel mineralization]
Show all
 209 aa
21.6 kDa 		Yes 0
AMTN-002
ENSP00000422452
ENST00000504451
Q6UX39 [Direct mapping]
Amelotin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0003674 [molecular_function]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005605 [basal lamina]
GO:0005911 [cell-cell junction]
GO:0007155 [cell adhesion]
GO:0031214 [biomineral tissue development]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0070169 [positive regulation of biomineral tissue development]
Show all
 208 aa
21.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.