Cell atlas - RALGAPA2 - The Human Protein Atlas

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RALGAPA2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	RALGAPA2
Gene description	Ral GTPase activating protein, alpha subunit 2 (catalytic)
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Group enriched (RT4, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA042707 , HPA043622
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RT4, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042707	A-431	Plasma membrane
	HPA042707	A-431	Cytosol
	HPA042707	U-2 OS	Plasma membrane
	HPA042707	U-2 OS	Cytosol
	HPA042707	U-251 MG	Plasma membrane
	HPA042707	U-251 MG	Cytosol
	HPA043622	RT4	Plasma membrane
	HPA043622	SiHa	Plasma membrane

GENE INFORMATION
Gene name	RALGAPA2 (HGNC Symbol)
Synonyms	AS250, C20orf74, dJ1049G11.4, KIAA1272, RapGAPalpha2
Description	Ral GTPase activating protein, alpha subunit 2 (catalytic) (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	p11.23
Chromosome location (bp)	20389552 - 20712488
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188559 (version 83.38)
Entrez gene	57186
UniProt	Q2PPJ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q2PPJ7
Antibodypedia	RALGAPA2 antibodies

PROTEIN BROWSER

RALGAPA2-002	RALGAPA2-007	RALGAPA2-008	RALGAPA2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RALGAPA2-002 ENSP00000400085 ENST00000430436	H7C1F9 [Direct mapping] Ral GTPase-activating protein subunit alpha-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005488 [binding] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0090630 [activation of GTPase activity] Show all	1740 aa 194.9 kDa	No	2
RALGAPA2-007 ENSP00000388695 ENST00000427175	H7BZA8 [Direct mapping] Ral GTPase-activating protein subunit alpha-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0090630 [activation of GTPase activity] Show all	250 aa 28.1 kDa	No	0
RALGAPA2-008 ENSP00000202677 ENST00000202677	Q2PPJ7 [Direct mapping] Ral GTPase-activating protein subunit alpha-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005488 [binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0032484 [Ral protein signal transduction] GO:0032880 [regulation of protein localization] GO:0046982 [protein heterodimerization activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0060178 [regulation of exocyst localization] GO:0061024 [membrane organization] GO:0090630 [activation of GTPase activity] Show all	1873 aa 210.8 kDa	No	2
RALGAPA2-201 ENSP00000481660 ENST00000620717	A0A087WYA8 [Direct mapping] Ral GTPase-activating protein subunit alpha-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0090630 [activation of GTPase activity] Show all	237 aa 26.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.