Expression of CNR2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Cannabinoid receptor 2 (macrophage)

Protein class

FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

CAB009719

GENE INFORMATION
Gene name	CNR2 (HGNC Symbol)
Synonyms	CB2
Description	Cannabinoid receptor 2 (macrophage) (HGNC Symbol)
Entrez gene summary	The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	23870526 - 23913362
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188822 (version 83.38)
Entrez gene	1269
UniProt	P34972 (UniProt - Evidence at protein level)
neXtProt	NX_P34972
Antibodypedia	CNR2 antibodies

PROTEIN BROWSER

CNR2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNR2-001 ENSP00000363596 ENST00000374472	P34972 [Direct mapping] Cannabinoid receptor 2 A0A024RAH7 [Target identity:100%; Query identity:100%] Cannabinoid receptor 2 (Macrophage), isoform CRA_a Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0001975 [response to amphetamine] GO:0004930 [G-protein coupled receptor activity] GO:0004949 [cannabinoid receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0016021 [integral component of membrane] GO:0019233 [sensory perception of pain] GO:0030425 [dendrite] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032229 [negative regulation of synaptic transmission, GABAergic] GO:0032496 [response to lipopolysaccharide] GO:0033004 [negative regulation of mast cell activation] GO:0038171 [cannabinoid signaling pathway] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043204 [perikaryon] GO:0045759 [negative regulation of action potential] GO:0050728 [negative regulation of inflammatory response] GO:0051001 [negative regulation of nitric-oxide synthase activity] Show all	360 aa 39.7 kDa	No	7