We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fractions of cases in malignant lymphomas, ovarian and colorectal cancers showed strong positivity. A majority of malignant gliomas and renal cancers were negative. Remaining malignant cells generally showed weak to moderate immunoreactivity.
GENE INFORMATION
Gene name
CNR2 (HGNC Symbol)
Synonyms
CB2
Description
Cannabinoid receptor 2 (macrophage) (HGNC Symbol)
Entrez gene summary
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]