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CNR2

GENERAL INFORMATION

Gene name

 CNR2

Gene description

 Cannabinoid receptor 2 (macrophage)

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (lymph node, spleen, tonsil, appendix)
GTEx:Group enriched (spleen, small intestine)
FANTOM5:Group enriched (tonsil, spleen, appendix, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
CAB009719
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lymph node, spleen, tonsil, appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, spleen, appendix, lymph node)

GENE INFORMATION

Gene name

 CNR2 (HGNC Symbol)

Synonyms

 CB2

Description

 Cannabinoid receptor 2 (macrophage) (HGNC Symbol)

Entrez gene summary

 The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 23870526 - 23913362

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188822 (version 83.38)

Entrez gene

 1269

UniProt

 P34972 (UniProt - Evidence at protein level)

neXtProt

 NX_P34972

Antibodypedia

 CNR2 antibodies

PROTEIN BROWSER
CNR2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNR2-001
ENSP00000363596
ENST00000374472
P34972 [Direct mapping]
Cannabinoid receptor 2
A0A024RAH7 [Target identity:100%; Query identity:100%]
Cannabinoid receptor 2 (Macrophage), isoform CRA_a
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
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GO:0001975 [response to amphetamine]
GO:0004930 [G-protein coupled receptor activity]
GO:0004949 [cannabinoid receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032229 [negative regulation of synaptic transmission, GABAergic]
GO:0032496 [response to lipopolysaccharide]
GO:0033004 [negative regulation of mast cell activation]
GO:0038171 [cannabinoid signaling pathway]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0045759 [negative regulation of action potential]
GO:0050728 [negative regulation of inflammatory response]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
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 360 aa
39.7 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.