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CNR2

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GENERAL INFORMATION

Gene name

 CNR2

Gene description

 Cannabinoid receptor 2 (macrophage)

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (HMC-1, U-698, HEL, Daudi)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HMC-1, U-698, HEL, Daudi)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CNR2 (HGNC Symbol)

Synonyms

 CB2

Description

 Cannabinoid receptor 2 (macrophage) (HGNC Symbol)

Entrez gene summary

 The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 23870526 - 23913362

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188822 (version 83.38)

Entrez gene

 1269

UniProt

 P34972 (UniProt - Evidence at protein level)

neXtProt

 NX_P34972

Antibodypedia

 CNR2 antibodies

PROTEIN BROWSER
CNR2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNR2-001
ENSP00000363596
ENST00000374472
P34972 [Direct mapping]
Cannabinoid receptor 2
A0A024RAH7 [Target identity:100%; Query identity:100%]
Cannabinoid receptor 2 (Macrophage), isoform CRA_a
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001975 [response to amphetamine]
GO:0004930 [G-protein coupled receptor activity]
GO:0004949 [cannabinoid receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032229 [negative regulation of synaptic transmission, GABAergic]
GO:0032496 [response to lipopolysaccharide]
GO:0033004 [negative regulation of mast cell activation]
GO:0038171 [cannabinoid signaling pathway]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0045759 [negative regulation of action potential]
GO:0050728 [negative regulation of inflammatory response]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
Show all
 360 aa
39.7 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.