Expression of POU3F4 in cancer - Summary

CANCER ATLAS

Gene description

POU class 3 homeobox 4

Protein class

Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA031984

GENE INFORMATION
Gene name	POU3F4 (HGNC Symbol)
Synonyms	BRN4, DFN3, DFNX2, OTF9
Description	POU class 3 homeobox 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]
Chromosome	X
Cytoband	q21.1
Chromosome location (bp)	83508250 - 83512127
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196767 (version 83.38)
Entrez gene	5456
UniProt	P49335 (UniProt - Evidence at protein level)
neXtProt	NX_P49335
Antibodypedia	POU3F4 antibodies

PROTEIN BROWSER

POU3F4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POU3F4-001 ENSP00000362296 ENST00000373200	P49335 [Direct mapping] POU domain, class 3, transcription factor 4 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007420 [brain development] GO:0007605 [sensory perception of sound] GO:0021879 [forebrain neuron differentiation] GO:0043565 [sequence-specific DNA binding] GO:0048839 [inner ear development] GO:0090103 [cochlea morphogenesis] GO:2001054 [negative regulation of mesenchymal cell apoptotic process] Show all	361 aa 39.4 kDa	No	0