Cell atlas - POU3F4 - The Human Protein Atlas

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POU3F4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	POU3F4
Gene description	POU class 3 homeobox 4
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (AF22)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	POU3F4 (HGNC Symbol)
Synonyms	BRN4, DFN3, DFNX2, OTF9
Description	POU class 3 homeobox 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]
Chromosome	X
Cytoband	q21.1
Chromosome location (bp)	83508250 - 83512127
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196767 (version 83.38)
Entrez gene	5456
UniProt	P49335 (UniProt - Evidence at protein level)
neXtProt	NX_P49335
Antibodypedia	POU3F4 antibodies

PROTEIN BROWSER

POU3F4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POU3F4-001 ENSP00000362296 ENST00000373200	P49335 [Direct mapping] POU domain, class 3, transcription factor 4 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007420 [brain development] GO:0007605 [sensory perception of sound] GO:0021879 [forebrain neuron differentiation] GO:0043565 [sequence-specific DNA binding] GO:0048839 [inner ear development] GO:0090103 [cochlea morphogenesis] GO:2001054 [negative regulation of mesenchymal cell apoptotic process] Show all	361 aa 39.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.