Tissue expression of POU3F4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	POU3F4
Gene description	POU class 3 homeobox 4
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Tissue enhanced (caudate)
FANTOM5:	Tissue enriched (caudate)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Pending retesting.
Reliability score	Uncertain based on 1 antibody. HPA031984
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (caudate)

GENE INFORMATION
Gene name	POU3F4 (HGNC Symbol)
Synonyms	BRN4, DFN3, DFNX2, OTF9
Description	POU class 3 homeobox 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]
Chromosome	X
Cytoband	q21.1
Chromosome location (bp)	83508250 - 83512127
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196767 (version 83.38)
Entrez gene	5456
UniProt	P49335 (UniProt - Evidence at protein level)
neXtProt	NX_P49335
Antibodypedia	POU3F4 antibodies

PROTEIN BROWSER

POU3F4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POU3F4-001 ENSP00000362296 ENST00000373200	P49335 [Direct mapping] POU domain, class 3, transcription factor 4 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007420 [brain development] GO:0007605 [sensory perception of sound] GO:0021879 [forebrain neuron differentiation] GO:0043565 [sequence-specific DNA binding] GO:0048839 [inner ear development] GO:0090103 [cochlea morphogenesis] GO:2001054 [negative regulation of mesenchymal cell apoptotic process] Show all	361 aa 39.4 kDa	No	0