Cell atlas - FAM3C - The Human Protein Atlas

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FAM3C

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	FAM3C
Gene description	Family with sequence similarity 3, member C
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (validated)
Mouse	Localized to the Golgi apparatus in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA043376 , HPA050548
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA043376	A-431	Golgi apparatus
HPA043376	U-2 OS	Golgi apparatus
HPA043376	U-251 MG	Golgi apparatus
HPA050548	A-431	Golgi apparatus
HPA050548	U-2 OS	No staining
HPA050548	U-251 MG	Golgi apparatus

MOUSE CELLS

Main location

Golgi apparatus

Mouse gene

ENSMUSG00000029672 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA050548	NIH 3T3	Golgi apparatus

GENE INFORMATION
Gene name	FAM3C (HGNC Symbol)
Synonyms	GS3876, ILEI
Description	Family with sequence similarity 3, member C (HGNC Symbol)
Entrez gene summary	This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]
Chromosome	7
Cytoband	q31.31
Chromosome location (bp)	121348851 - 121396364
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196937 (version 83.38)
Entrez gene	10447
UniProt	Q92520 (UniProt - Evidence at protein level)
neXtProt	NX_Q92520
Antibodypedia	FAM3C antibodies

PROTEIN BROWSER

FAM3C-001	FAM3C-002	FAM3C-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM3C-001 ENSP00000353025 ENST00000359943	Q92520 [Direct mapping] Protein FAM3C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005794 [Golgi apparatus] GO:0007275 [multicellular organismal development] GO:0008150 [biological_process] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0070062 [extracellular exosome] Show all	227 aa 24.7 kDa	No	0
FAM3C-002 ENSP00000408636 ENST00000412653	C9JMN4 [Direct mapping] Protein FAM3C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	151 aa 16.2 kDa	No	0
FAM3C-004 ENSP00000414940 ENST00000426156	C9JP35 [Direct mapping] Protein FAM3C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	109 aa 11.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.