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FAM3C

GENERAL INFORMATION

Gene name

 FAM3C

Gene description

 Family with sequence similarity 3, member C

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA043376 , HPA050548
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FAM3C (HGNC Symbol)

Synonyms

 GS3876, ILEI

Description

 Family with sequence similarity 3, member C (HGNC Symbol)

Entrez gene summary

 This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]

Chromosome

 7

Cytoband

 q31.31

Chromosome location (bp)

 121348851 - 121396364

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196937 (version 83.38)

Entrez gene

 10447

UniProt

 Q92520 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92520

Antibodypedia

 FAM3C antibodies

PROTEIN BROWSER
FAM3C-001
FAM3C-002
FAM3C-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FAM3C-001
ENSP00000353025
ENST00000359943
Q92520 [Direct mapping]
Protein FAM3C
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005794 [Golgi apparatus]
GO:0007275 [multicellular organismal development]
GO:0008150 [biological_process]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0070062 [extracellular exosome]
Show all
 227 aa
24.7 kDa 		No 0
FAM3C-002
ENSP00000408636
ENST00000412653
C9JMN4 [Direct mapping]
Protein FAM3C
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
Show all
 151 aa
16.2 kDa 		No 0
FAM3C-004
ENSP00000414940
ENST00000426156
C9JP35 [Direct mapping]
Protein FAM3C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
Show all
 109 aa
11.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.