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SERPINA1

CANCER ATLAS

Gene description

 Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

Protein class

 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000927
HPA001292
CAB013211
CAB016648
CAB073396

GENE INFORMATION

Gene name

 SERPINA1 (HGNC Symbol)

Synonyms

 A1A, A1AT, AAT, alpha-1-antitrypsin, alpha1AT, PI, PI1

Description

 Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q32.13

Chromosome location (bp)

 94376747 - 94390693

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197249 (version 83.38)

Entrez gene

 5265

UniProt

 P01009 (UniProt - Evidence at protein level)

neXtProt

 NX_P01009

Antibodypedia

 SERPINA1 antibodies

PROTEIN BROWSER
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SERPINA1-001
SERPINA1-002
SERPINA1-003
SERPINA1-004
SERPINA1-006
SERPINA1-007
SERPINA1-008
SERPINA1-010
SERPINA1-011
SERPINA1-015
SERPINA1-016
SERPINA1-017
SERPINA1-201
SERPINA1-202
SERPINA1-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SERPINA1-001
ENSP00000390299
ENST00000440909
P01009 [Direct mapping]
Alpha-1-antitrypsin Short peptide from AAT
E9KL23 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 44a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001948 [glycoprotein binding]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030134 [ER to Golgi transport vesicle]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 418 aa
46.7 kDa 		Yes 0
SERPINA1-002
ENSP00000376803
ENST00000393088
P01009 [Direct mapping]
Alpha-1-antitrypsin Short peptide from AAT
E9KL23 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 44a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001948 [glycoprotein binding]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030134 [ER to Golgi transport vesicle]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 418 aa
46.7 kDa 		Yes 0
SERPINA1-003
ENSP00000385960
ENST00000404814
P01009 [Direct mapping]
Alpha-1-antitrypsin Short peptide from AAT
E9KL23 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 44a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001948 [glycoprotein binding]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030134 [ER to Golgi transport vesicle]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 418 aa
46.7 kDa 		Yes 0
SERPINA1-004
ENSP00000376802
ENST00000393087
P01009 [Direct mapping]
Alpha-1-antitrypsin Short peptide from AAT
E9KL23 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 44a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001948 [glycoprotein binding]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030134 [ER to Golgi transport vesicle]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 418 aa
46.7 kDa 		Yes 0
SERPINA1-006
ENSP00000386094
ENST00000402629
P01009 [Direct mapping]
Alpha-1-antitrypsin Short peptide from AAT
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001948 [glycoprotein binding]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030134 [ER to Golgi transport vesicle]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 359 aa
40.3 kDa 		Yes 0
SERPINA1-007
ENSP00000452452
ENST00000557492
A0A0B4J278 [Direct mapping]
Alpha-1-antitrypsin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 144 aa
15.7 kDa 		Yes 0
SERPINA1-008
ENSP00000416354
ENST00000449399
P01009 [Direct mapping]
Alpha-1-antitrypsin Short peptide from AAT
E9KL23 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 44a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001948 [glycoprotein binding]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030134 [ER to Golgi transport vesicle]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 418 aa
46.7 kDa 		Yes 0
SERPINA1-010
ENSP00000451826
ENST00000557118
G3V4I7 [Direct mapping]
Alpha-1-antitrypsin
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 22 aa
2.2 kDa 		Yes 0
SERPINA1-011
ENSP00000451098
ENST00000556955
G3V387 [Direct mapping]
Alpha-1-antitrypsin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 117 aa
12.7 kDa 		Yes 0
SERPINA1-015
ENSP00000452480
ENST00000553327
G3V5R8 [Direct mapping]
Alpha-1-antitrypsin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 92 aa
9.9 kDa 		Yes 0
SERPINA1-016
ENSP00000450561
ENST00000554720
G3V2B9 [Direct mapping]
Alpha-1-antitrypsin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 105 aa
11.8 kDa 		No 0
SERPINA1-017
ENSP00000452169
ENST00000556091
G3V544 [Direct mapping]
Alpha-1-antitrypsin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 156 aa
17.1 kDa 		Yes 0
SERPINA1-201
ENSP00000348068
ENST00000355814
P01009 [Direct mapping]
Alpha-1-antitrypsin Short peptide from AAT
E9KL23 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 44a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001948 [glycoprotein binding]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030134 [ER to Golgi transport vesicle]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 418 aa
46.7 kDa 		Yes 0
SERPINA1-202
ENSP00000408474
ENST00000437397
P01009 [Direct mapping]
Alpha-1-antitrypsin Short peptide from AAT
E9KL23 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 44a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001948 [glycoprotein binding]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030134 [ER to Golgi transport vesicle]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 418 aa
46.7 kDa 		Yes 0
SERPINA1-203
ENSP00000416066
ENST00000448921
P01009 [Direct mapping]
Alpha-1-antitrypsin Short peptide from AAT
E9KL23 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 44a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001948 [glycoprotein binding]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030134 [ER to Golgi transport vesicle]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 418 aa
46.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.